Extracts of leaves were obtained by the classical method of continuous extraction using soxhlet apparatus. In addition, due to the medicinal importance of genus inula, this paper reports the isolation and identification of six major constituents fractions from extracts of leaves of syrian inula viscosa l. The leaves and stems of the plant are coated with a sticky resin secreted from glandular hairs growing on the surface of the leaves. Antibacterial activity and chemical composition of essential. Antitumor effect of inula viscosa extracts on dmbainduced. Type a value in the celsius field to convert the value to fahrenheit. Possible use of inula viscosa dittrichia viscosa l. Dec 01, 2016 biogeographical and physiological aspects of the invasion by dittrichia ex inula viscosa w. For our knowledge, the chemical composition of syrian i. Biology of dittrichia viscosa, a mediterranean ruderal. Conventional therapy of crc is limited by severe side effects and by the development of resistance. Inula viscosa iv is a wellknown medicinal perennial herb in traditional medicine. Antiproliferative effect and induction of apoptosis by. When such extracts were sprayed on the leaf surface of crop plants they effectively controlled downy mildew in grape, cucumber and tabacco.
Inula viscosa against the braineating amoeba naegleria fowleri by activation of programmed cell death, acs chemical neuroscience 2020. In pakistan this plant is known as naro and kolmur. Many of them are indicated in traditional medicine, e. The infusions show activity against hematophagic insects, mosquitos, flies, and horseflies. Inula viscosa, belonging to the genus inula asteraceae, is a perennial plant considered as one of the most essential medicinal plants around the mediterranean basin. Kebir article online a valorization of inula viscosa waste extraction, modeling of isotherm, and kinetic for the tartrazine dye adso rption. Inula viscosa that belongs to asteraceae family is a strong smelling plant. This extract is useful in the treatment of human beings suffering from infectious diseases. Quantitative and qualitative analyses of inula viscosa quantitative and quantitative analyses area % were performed by shimadzu gcms gc17a gas chromatograph with qp5000 mass spectrometer.
Grows freely in a sunny position in ordinary garden soil1. Inula is a large genus containing about 120 species that belongs to the family asteraceae. Chemical composition and in vitro activity of plant. It is widely used in traditional medicine in algeria, especially in farming areas for the treatment of various diseases such. The essential oil yields were very higher for both samples 3.
Algeria, antibacterial activity, chemotypes, essential oil, inula viscosa introduction inula viscosa l. Tlc analyses revealed at least 7 fungicidal compounds. Ethnobotanical study showed that the plant is very used in traditional medicine as an antiviral 11, antiseptic, antibacterial, healing 12, and antifungal 14, 15. Antioxidant activities and total phenol content of inula viscosa. This invention relates to the preparation of an extract of inula and related species such as inula viscosa and inula graveolens which belong to the family compositae which is useful in therapy, in particular as bacteriostatic and fungistatic agent. In this study the possibility of using liquid inula viscosa dittrichia viscosa l. Several studies have shown that some inula species contain some interesting compounds with. Leaf structure and cytochemical investigation of secretory. Inula viscosa, folk medicine, flavonoids contents, polyphenols, dpph. Steam distillation of aerial parts of inula viscosa yielded light yellowcolored essential oil 0. Gcms chromatogram of the essential oil extracted from the aerial parts of syrian inula viscosa l. Aiton asteraceae is a herbaceous perennial plant widely spread in the mediterranean area.
Chemotypes and antibacterial activities of inula viscosa. Exploring the antiinfective value of inuloxin a isolated from inula viscosa against the brain. Wo2003017768a2 infusion of inula viscosa for controlling. Aiton sticky fleabane is popular medicinal plant in the family asteraceae. Isolation and identification of six terpenes extracted from. Antitumor effect of inula viscosa extracts on dmbainduced skin. Organic eprints fungicidal preparations from inula viscose. Four new and 14 known compounds have been isolated from inula viscosa of jordanian origin. The present invention refers to infusions of inula viscosa, and a process to obtain the mentioned infusions by treatment with ethyl alcohol, vegetable oil, or water.
The opinions expressed here are the views of the writer and do. It has long, narrow leaves that are pointed at both ends and have teeth along the edges and glandular hairs on the surfaces. Antiproliferative, antimicrobial and apoptosis inducing. Department of pharmaceutical sciences, dibrugarh university, dibrugarh786004, assam, department of pharmaceutical sciences, dibrugarh university, dibrugarh786004, assam, department. Analysis of the chemical composition of essential oil from. Research article open access pure isolates and preparative.
The most common of these are inula acaulis, inula acuminate, inula candida, inula cappa, inula falconeri, inula helvetica, inula nervosa, inula racemosa, inula stewartii and inula subfloccosa. This genus includes more than 100 species, widely distributed throughout europe, africa and asia including india. Previous studies isolated and identified various chemical compounds in inula species including flavonoids 29,30 terpenes, 31 sesquiterpenoids 32,33 and sesquiterpene lactones. Pdf effect of clammy inula inula viscose plant extract in. New sesquiterpenoids from the jordanian medicinal plant. As already said, uses on inula viscosa in traditional medicine practiced by the arabs in israel, a. Dittrichia viscosa which belongs to the asteraceae family is frequently used to treat hematomas.
Pdf cytotoxic effect and chemical composition of inula viscosa. In this research, it was found that the palestinian flora inula viscosa alcoholic extract has a significant and promising. Antihypertensive and vasodilator effects of methanolic. The chemical composition was analyzed by semipreparative hplc and then identified by gcms. The antiinflammatory activity of these plants was studied both in vitro on lipopolysaccharide lpsstimulated j774a. Inula grantioides, another important medicinal species of inula, has a wide distribution in sind province. Inula viscosa extract inhibits growth of colorectal cancer. Traditional medicine uses of inula viscosa, folk medicine practices and refernces from traditional medicine books. Evaluation of antibacterial activity of inula viscosa l antibacterial activity of inula viscosa l. Antiproliferative effect and induction of apoptosis by inula viscosa l. Antiinflammatory and antioxidant activities of inula viscosa. Pdf effect of clammy inula inula viscose plant extract. Inula viscosa is a perennial plant native to the mediterranean basin.
Pdf antioxidant activities and total phenol content of inula viscosa. Feb 04, 2020 inula viscosa, belonging to the genus inula asteraceae, is a perennial plant considered as one of the most essential medicinal plants around the mediterranean basin. Effet antihypertenseur des feuilles d inula viscosa. The inula viscosa extract exhibited powerful antiproliferative and cytotoxic activities on raji cell line, showing a dose and timedependent decrease in cell viability, obtained by cell cycle arrest in the g2m phase and an increase in cell apoptosis. Inula is a large genus of about 90 species of flowering plants in the family asteraceae, native to europe, asia and africa. Pdf on jan 10, 2016, m messaoudi and others published cytotoxic effect and chemical composition of inula viscosa from three different. Analysis of extracts from palestinian inula viscosa for their. Systolic blood pressure was measured using the indirect tailcuff plethysmographic method tcp. Inula graveolens stace 1991 and dittrichia viscosa syn. This plant has a local use in lasbela for treating patients suffering from asthma burdi et al. Isolation and identification of six terpenes extracted. The taxonomic revision of the dittrichia genus showed that i.
Preparation of inula viscosa macerate the plants of inula viscosa have been taken in the countryside of rosignano solvay li. Inula viscosa, folk medicine, flavonoids contents, polyphenols, dpph, reducing power. Apr 20, 2020 dittrichia graveolens inula graveolens a related species in malta inula graveolens was noticed to grow alongside inula viscosa in many sites, dittrrichia its presence was more often encountered in waste and fallow grounds then in less disturbed places. Molecules free fulltext antiproliferative, antimicrobial. Asteraceae is a medicinal plant widely used as a folk. In traditional pharmacopeia, several species of ferula genus and d. The results showed that inula viscosa extracts inhibit the development of papilloma in.
Evaluation of cytotoxicity and genotoxicity of inula viscosa leaf extracts with. Epub jan inula viscosa extracts induces telomere shortening and apoptosis. The analysis led to the identification of 68 components in. They may be annuals, herbaceous perennials or subshrubs that vary greatly in size, from small species a few centimeters tall to enormous perennials over 3 m 10 ft tall. Medicinal plantderived compound destroys braineating amoeba. Plants of the genus inula are perennial herbs of the family asteraceae. Inula viscosa is a shrub that grows around the mediterranean basin and considered as an important palestinian traditional medicinal herb. Inula viscosa collected from hebron mountains palestine using different solvents with subsequent analysis of the extracts for their lipid, phenolic and flavonoid contents and antioxidant and antibacterial activities. Antiinflammatory and antioxidant activities of inula. Dittrichia viscosa, also known as false yellowhead, woody fleabane, sticky fleabane and yellow fleabane, is a flowering plant in the daisy family dittrichia viscosa is a highly branching perennial common throughout the mediterranean basin. Plant material inula viscosa materials whole plant, leaves, steams, flower, and roots were.
View of chemotypes and antibacterial activities of inula viscosa. Dittrichia viscosa, locally called magramen, is a herbaceous perennial plant widely distributed in the mediterranean area. Medicinal plantderived compound destroys braineating. Effect of extraction solventtechnique on their antioxidant ability. Effect of inula viscose plant extract a and the fungicide iprodione on beans gray mould disease. Return to article details chemotypes and antibacterial activities of inula viscosa essential oils from algeria download download pdf. Greuter, a ruderal species in the mediterranean basin. The essential oils of the annual stinking fleabane dittrichia graveolens syn. Apr 10, 2019 colorectal cancer crc is the second most common cancer in females and the third in males worldwide.
The effect of native medical plant clammy inula inula viscosa l. To investigate antioxidant activity, total phenolic and. Analysis of extracts from palestinian inula viscosa for. Received mar 2017, accepted 24 apr 2017, published 18 may 2017. Pure isolates and preparative hplc fractions or crude extract. The main compounds of the two essential oils analyzed were. In recent times, several experimental studies carried out on i. Biology of dittrichia viscosa, a mediterranean ruderal plant. Extracts made from the shoots of this plant exhibited a strong fungicidal activity in vitro and in vivo. The present invention concerns an inula viscosa extract for use in treating arthritis and for use an antiinflammatory, antibacterial, antifungal, antioxidant, antiyeast agent. Antiproliferative and proapoptotic effects of inula viscosa. The invention further concerns a method for cultivating inula viscosa plants and an optimized efficient extraction process utilizing ethylacetate as the solvent for obtaining an extract characterized by the.
The chromatogram of aerial parts is shown in figure 1 figure 1. Promising medicinal plant inula viscosa l antiproliferative. To the best of our knowledge, this is the first report gives information on the kinetic of extraction of i. It is used for different therapeutic purposes, such as. Inula viscosa asteraceae is amedicinal plant widely used by mediterranean population in folk medicine to treat different diseases. Were collected from fields in rural damascus in syria. They carry yellow daisylike composite flowerheads often with narrow rayflorets. They do not leach from the vacuole if fixation temperatures are kept low. Its used, in north african folk medicine, to treat diabetes and. The aim of this work is to evaluate the antitumor e. Can alternative host plant and prey affect phytophagy and biological.
The antiproliferative activity was tested against three cell lines using the mtt assay. This page was last edited on 14 december 2019, at 20. Inula viscosa is a strong smelling plant, woody at the base and having numerous yellow flowered heads at the top of the stem 3. Inula helenium is also used in asia as are inula japonica and inula britannica flowers reid 1987, inula racemosa and inula royleana ketai et al 2000, zhao et al 2006. Magramane is a widespread plant in the mediterranean basin 9,10. Bjoc use of costic acid, a natural extract from dittrichia viscosa.
The antiproliferative and antimicrobial effects of thirteen compounds isolated from inula viscosa l. We studied the potential role of two alternative host plants for n. The genus inula includes more than 100 species, widespread in the mediterranean countries and four inula viscosa l. They may be annuals, herbaceous perennials or subshrubs that vary greatly in size, from small species a few centimeters tall to enormous perennials over 3 m tall. It is widely used in traditional medicine in algeria, especially in farming areas for the treatment of various diseases such as bronchitis, diabetes and injuries. Its oil consists mainly of sesquiterpenoid lactones. Frontiers inula viscosa extract inhibits growth of. The treatment with inula viscosa caused downregulation of genes involved in cell cycle and. Klebsiella pneumoniae however, was previously cultivated in brain heart infusion. Dittrichia viscosa false yellowhead pfaf plant database.
New sesquiterpenoids from the jordanian medicinal plant inula. Antioxidant and chemical properties of inula helenium root. Pdf valorization of inula viscosa waste extraction. The genus inula includes 90 species which are hardy eurasian perennials bown 1995 and 19 species found in europe tutin et al 1976. Comprehensive phytochemical analysis, antioxidant and. In this paper a kinetic study of steam distillation of inula viscosa essential oil, analysis by gcms and antifungal activity were reported. Compound from medicinal herb kills braineating amoebae in. Inula viscosa, which is native to southeast europe nikolakakis. Inula viscosa iv is a wellknown medicinal perennial herb in. Us4254112a inula extract, its method of preparation and its.
Aug 16, 2015 the outcome of this study shows that inula viscosa leaves can be considered as a consolidated source of essential fatty acids, mainly linolenic and linoleic acids. Files are available under licenses specified on their description page. The antihypertensive effect of the aqueous extract obtained from inula viscosa leaves was studied in hypertensive rats. Therefore, additional therapies are needed in order to combat the problem of selectivity and drug resistance in crc patients. Leaves were trimmed to 12 cm in length and placed in 150. Inula viscosa leaves were dipped in 70% etoh for 30 s, stirred in 1% water solution of commercial bleach containing 4. Moreover it will be interesting to use some in vivo models to evaluate the antitumor activity of these plant extracts. Bergaoui, mansour znati, guido flamini, roberta ascrizzi, hichem ben jannet, isocostic acid, a promising bioactive agent from the essential oil of inula viscosa l. Investigation of traditional palestinian medicinal plant. The microdilution method was used to study the antimicrobial activity against two gram positive bacteria, two gram negative bacteria and one fungus. Moreover, they contain appreciable amounts of phenolic compounds with phenolic acids, recognized for their high biological activities, being the most abundant. Inula helenium, a perennial plant widely occurring in europe and east asia, belongs to the compositae family. All structured data from the file and property namespaces is available under the creative commons cc0 license. Among most important medicinal plants in india, inula is a large genus of about 90 species of flowering plants belonging to asteraceae family.
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